Pyridine, 2-fluoro-3-iodo-
2-fluoro-3-iodopyridine
CAS: 113975-22-7
Molecular Formula: C5H3FIN
Pyridine, 2-fluoro-3-iodo- - Names and Identifiers
| Name | 2-fluoro-3-iodopyridine |
| Synonyms | uoro-3-iodopyridine 2-Fluor-3-iodpyridin 2-fluoro-3-iodopyridine 2-Fluoro-3-iodopyridine 2-FLUORO-3-IODOPYRIDINE Pyridine, 2-fluoro-3-iodo- PYRIDINE, 2-FLUORO-3-IODO- |
| CAS | 113975-22-7 |
| InChI | InChI=1/C5H3FIN/c6-5-4(7)2-1-3-8-5/h1-3H |
| InChIKey | WCDCAXVNBOLWNO-UHFFFAOYSA-N |
Pyridine, 2-fluoro-3-iodo- - Physico-chemical Properties
| Molecular Formula | C5H3FIN |
| Molar Mass | 222.99 |
| Density | 2.046±0.06 g/cm3(Predicted) |
| Melting Point | 45 °C |
| Boling Point | 99°C/17mmHg(lit.) |
| Flash Point | >110°C |
| Vapor Presure | 0.1mmHg at 25°C |
| Appearance | Light clear solid |
| pKa | -2.45±0.10(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
| Sensitive | Light Sensitive |
| Refractive Index | 1.599 |
| MDL | MFCD03095287 |
Pyridine, 2-fluoro-3-iodo- - Risk and Safety
| Risk Codes | R20/21/22 - Harmful by inhalation, in contact with skin and if swallowed. R36/37/38 - Irritating to eyes, respiratory system and skin. R41 - Risk of serious damage to eyes R37/38 - Irritating to respiratory system and skin. |
| Safety Description | S22 - Do not breathe dust. S26 - In case of contact with eyes, rinse immediately with plenty of water and seek medical advice. S36/37/39 - Wear suitable protective clothing, gloves and eye/face protection. S39 - Wear eye / face protection. S37 - Wear suitable gloves. |
| WGK Germany | 3 |
| HS Code | 29333990 |
| Hazard Note | Irritant |
Pyridine, 2-fluoro-3-iodo- - Introduction
2-Fluoro-3-iodopyridine is an organic compound with the chemical formula C5H2FNI. The following is a description of its nature, use, preparation and safety information:
Nature:
2-Fluoro-3-iodopyridine is a solid with a white to slightly yellow crystalline form. It has high solubility and can be dissolved in common organic solvents. Stable at room temperature, but decomposed when heated.
Use:
2-Fluoro-3-iodopyridine is often used as a starting material or an intermediate in organic synthesis. It has a wide range of applications in the field of medicine, and can be used as an important raw material for drug synthesis. It can also be used in the field of biomarker synthesis, pesticide synthesis and so on.
Method:
There are two main methods for the preparation of 2-fluoro-3-iodopyridine:
1. Fluorination reaction: 2-iodopyridine is first reacted with a fluorinating agent, such as hydrogen fluoride (HF), boron trifluoride (BF3) or cuprous fluoride (CuF), etc., to obtain 2-fluoro-3-iodopyridine.
2. Iodination reaction: 2-fluoro-3-chloropyridine or 2-fluoro-3-bromopyridine is reacted with iodine to replace chlorine or bromine to give 2-fluoro-3-iodopyridine.
Safety Information:
2-Fluoro-3-iodopyridine may have certain toxicity and irritation to the human body, so the following safety precautions should be paid attention to during operation and storage:
1. avoid direct contact with skin and eyes, avoid inhalation of its vapor or dust.
2. when in use, need to wear protective gloves, goggles and protective clothing and other personal protective equipment.
3. Use should be operated in a well-ventilated environment to avoid excessive vapor concentration.
4. avoid contact with combustibles, and keep away from fire and high temperature environment when stored.
5. when inadvertently contact or inhalation of the compound, should be promptly rinsed with water, and immediately seek medical attention.
Nature:
2-Fluoro-3-iodopyridine is a solid with a white to slightly yellow crystalline form. It has high solubility and can be dissolved in common organic solvents. Stable at room temperature, but decomposed when heated.
Use:
2-Fluoro-3-iodopyridine is often used as a starting material or an intermediate in organic synthesis. It has a wide range of applications in the field of medicine, and can be used as an important raw material for drug synthesis. It can also be used in the field of biomarker synthesis, pesticide synthesis and so on.
Method:
There are two main methods for the preparation of 2-fluoro-3-iodopyridine:
1. Fluorination reaction: 2-iodopyridine is first reacted with a fluorinating agent, such as hydrogen fluoride (HF), boron trifluoride (BF3) or cuprous fluoride (CuF), etc., to obtain 2-fluoro-3-iodopyridine.
2. Iodination reaction: 2-fluoro-3-chloropyridine or 2-fluoro-3-bromopyridine is reacted with iodine to replace chlorine or bromine to give 2-fluoro-3-iodopyridine.
Safety Information:
2-Fluoro-3-iodopyridine may have certain toxicity and irritation to the human body, so the following safety precautions should be paid attention to during operation and storage:
1. avoid direct contact with skin and eyes, avoid inhalation of its vapor or dust.
2. when in use, need to wear protective gloves, goggles and protective clothing and other personal protective equipment.
3. Use should be operated in a well-ventilated environment to avoid excessive vapor concentration.
4. avoid contact with combustibles, and keep away from fire and high temperature environment when stored.
5. when inadvertently contact or inhalation of the compound, should be promptly rinsed with water, and immediately seek medical attention.
Last Update：2024-04-09 20:49:11
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